Table 2.

Frequency of response to mismatched HLA antigens.

Responsea	HLA-mismatched antigen
	A	B	DR	DQB
Mean overall	53.2	42.4	52.6	59.0
Rangeb	30.8–76.2	15.0–66.1	40.0–73.0	47.4–90.0
Mean with no cross-reactive antigen in patient	60.2	52.0	61.0	71.3
Mean with cross-reactive antigen in patient	49.7	35.5	43.0	45.5

Frequencies of antibodies, defined by multiplexed bead assays, to mismatched HLA antigens were determined from 703 renal transplant patients who had no detectable donor-specific antibody before transplantation. The impact of patients having antigens in their phenotype that were cross-reactive with the mismatched antigen was also assessed. Adapted from Lucas et al. (80).

^aPercentage of mismatched patients who made antibody.

^bThe range of antibody response to different antigens within the locus.