Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Nov 14;5(11):e269. doi: 10.1038/oncsis.2016.67

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016 The Author(s)

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Notch3 can reverse EMT induced by TGF-β1. (a) Morphological changes of MCF-7 cells before and after TGF-β1 treatment as well as TGF-β1 treatment combined with N3ICD overexpression. (b) RT-PCR confirms that MCF-7 cells undergo EMT after TGF-β1 treatment. (c) Western blotting confirms that MCF-7 cells undergo EMT after TGF-β1 treatment. (d) RT-PCR confirms that ectopically overexpressed N3ICD can reverse EMT induced by TGF-β1 in MCF-7 cells. (e) Western blotting confirms that ectopically overexpressed N3ICD can reverse EMT induced by TGF-β1 in MCF-7 cells. Data are presented as the mean±s.d. of three experiments. *P<0.05, **P<0.01 and ***P<0.001 (Student's t-test) as compared with control cells.