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. 2016 Nov 28;5(11):e271. doi: 10.1038/oncsis.2016.68

Figure 1.

Figure 1

FOXK1 expression is higher in human CRC Tissues. (a) Expression pattern of FOXK1 mRNA in normal and tumour tissues. FOXK1 mRNA expression in various types of cancer was searched in the GENT database (available at http://medical-genomics.kribb.re.kr/GENT/). Boxes represent the median and the 25th and 75th percentiles; dots represent outliers. Red boxes represent tumour tissues; green boxes represent normal tissues. Red and green dashed lines represent the average value of all tumour and normal tissues, respectively. The asterisk indicates the significant increase of FOXK1 expression in colon tumours compared with normal tissues. FOXK1 mRNA expression of colon tissue: blue dotted lines. (b) Expression of FOXK1 by qRT–PCR in 10 pairs of colon cancer (tumour) and matched non-cancerous colonic tissues (normal). All of these experiments were repeated three times with identical findings. (c) On average, higher expression level of FOXK1 was found in tumour than in normal tissues (n=10). ****P<0.001. (d) In eight selected cases, higher expression of FOXK1 in tumour tissues was confirmed by immunohistochemistry (n=8). Scale bars, 200 μm in d.