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. 2016 Nov 28;5(11):e271. doi: 10.1038/oncsis.2016.68

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Copyright © 2016 The Author(s)

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Positive correlation between FHL2 and FOXK1 expression in CRC. (a) FHL2 (a and c) and FOXK1 (b and d) expression in normal or cancerous colorectal tissue specimens were detected by IHC assays. These figures were the representatives of colorectal tissues from 87 cancerous and non-cancerous patients. Normal mouse IgG was used as the isotype control for the first antibody (a and b). (b) Average scores of the two proteins in normal and cancerous CRC tissues. ****P<0.001 between normal and cancer tissues. (c) FHL2 and FOXK1-positive staining were quantified and a Spearman correlation was performed. ****P<0.001. (d) Kaplan–Meier overall survival analysis of CRC patients. Survival analysis was performed according to the expression status of FHL2 (a), FOXK1 (b) and the combined expression status of FHL2 and FOXK1 (c), respectively. Scale bars represent 100 μm in a.