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. 2016 Nov 7;5(11):e268. doi: 10.1038/oncsis.2016.69

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Copyright © 2016 The Author(s)

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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CD44 rescue antagonizes SALL4 knockdown-mediated inhibition of tumour growth and metastasis in vivo. (a) Representative images of tumours from mice injected with control and SALL4 knockdown gastric cancer cells with or without CD44 overexpression. (b) The mean weight of tumours from mice injected with control and SALL4 knockdown gastric cancer cells with or without CD44 overexpression. (c) The mean volume of tumours from mice injected with control and SALL4 knockdown gastric cancer cells with or without CD44 overexpression. (d) HE staining of tumour tissue sections from mice injected with control and SALL4 knockdown gastric cancer cells with or without CD44 overexpression. (e) Immunohistochemical staining for SALL4 in tumour tissue sections from mice injected with control and SALL4 knockdown gastric cancer cells with or without CD44 overexpression. (f) Immunohistochemical staining for CD44 in tumour tissue sections from mice injected with control and SALL4 knockdown gastric cancer cells with or without CD44 overexpression. (g) Western blot analyses of Oct4, Sox2, Nanog, c-Myc and CD44 expression in control and SALL4 knockdown gastric cancer cells with or without CD44 overexpression. *P<0.05, compared to sh-Ctrl+Vector group; ^#P<0.05, compared to sh-SALL4-2+Vector group.