Table 1. Summary of variant allele fractions of AR-GSRs in prostate cancer.
| Patient | Tumour | Tumour type | AR-GSR | Break fusion junction coordinates (hg19) | Variant allele fraction (SHEAR) |
|---|---|---|---|---|---|
| C-4 | A | CRPC met | Deletion 1 | chrX:66,804,042 (+)/chrX:66,816,507 (+) | 7.32% |
| A | CRPC met | Deletion 2 | chrX:66,754,961 (+)/chrX:66,843,254 (+) | 7.88% | |
| C-6 | A | CRPC met | Deletion 1 | chrX:66,934,778 (+)/chrX:66,942,396 (+) | 46.99% |
| A | CRPC met | Duplication | chrX:66,942,924 (+)/chrX:66,939,551 (+) | 74.15% | |
| A | CRPC met | Deletion 2 | chrX:66,940,040 (+)/chrX:66,943,474 (+) | 42.68% | |
| B | CRPC met | Deletion 1 | chrX:66,934,778 (+)/chrX:66,942,396 (+) | 43.45% | |
| B | CRPC met | Duplication | chrX:66,942,924 (+)/chrX:66,939,551 (+) | 49.19% | |
| B | CRPC met | Deletion 2 | chrX:66,940,040 (+)/chrX:66,943,474 (+) | 38.23% | |
| C-7 | A | CRPC met | Deletion | chrX:49,150,734 (+)/chrX:66,779,010 (+) | 4.26% |
| B | CRPC met | Deletion | chrX:49,150,734 (+)/chrX:66,779,010 (+) | 5.40% | |
| C-9 | A | CRPC met | Translocation | chrX:66,909,163 (+)/TTTAG/chr11:79,397,735 (+) | 13.74% |
| C-12 | A | CRPC met | Deletion | chrX:66,786,453 (+)/chrX:66,862,260 (+) | 13.13% |
| A | CRPC met | Duplication 1 | chrX:66,765,788 (+)/chrX:66,738,768 (+) | 4.71% | |
| A | CRPC met | Duplication 2 | chrX:66,909,930 (+)/chrX:66,530,990 (+) | 33.25% | |
| B | CRPC met | Deletion | chrX:66,786,453 (+)/chrX:66,862,260 (+) | 46.28% | |
| B | CRPC met | Duplication 1 | chrX:66,765,788 (+)/chrX:66,738,768 (+) | 25.87% | |
| B | CRPC met | Duplication 3 | chrX:66,767,448 (+)/chrX:66,026,083 (+) | 5.66% | |
| C-14 | A | CRPC met | Inversion 1 | chrX:65,828,372 (−)/chrX:66,816,576 (+) | 4.52% |
| A | CRPC met | Inversion 2 | chrX:66,919,966 (+)/chrX:67,012,163 (−) | 1.62% | |
| B | CRPC met | Inversion 3 | chrX:66,908,944 (−)/66,922,090 (+) | 1.86% | |
| B | CRPC met | Duplication | chrX:66,929,712 (+)/chrX:66,921,594 | 2.65% | |
| P-1 | TURP | local CRPC | Inversion | chrX:66,935,187 (+)/chrX:66,938,063 (−) | not determined/imprecise |
| P-14 | TURP | local CRPC | Duplication | chrX:67,337,657 (+)/chrX:66,909,110 (+) | 2.19% |
AR-GSR, AR genomic structural rearrangement; CRPC, castration-resistant prostate cancer; met, metastases; PC, prostate cancer; TURP, transurethral resection of the prostate.