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. 2016 Jun 10;6(6):e434. doi: 10.1038/bcj.2016.41

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Mutant p53 results in reduced survival, but phenotypically similar disease progression in Eμ-TCL1 mice. (a) Kaplan–Meier curves of Eμ-TCL1;p53^R172H/+ and Eμ-TCL1 mice. (b) Flow cytometry data demonstrating the CD5⁺/CD19⁺ immunophenotypes in the peripheral blood of Eμ-TCL1;p53^R172H/+ and Eμ-TCL1 mice at 4, 6 and 8 months of age. Cells were gated by their expression of CD5, CD19 and CD5/CD19. (c) Bar graph representing the percent of CD5⁺/CD19⁺ cells in the peripheral blood of Eμ-TCL1;p53^R172H/+ (n=6) and Eμ-TCL1 (n=6) mice at 4, 6 and 8 months of age. NS represents non-significant values (P>0.05) (d–f) Hematoxylin and eosin staining of tumor burdened spleens, lymph nodes, livers of Eμ-TCL1;p53^R172H/+ and Eμ-TCL1 mice. The scale bar represents 100 microns.