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. 2016 Oct;57(5):457–464. doi: 10.3325/cmj.2016.57.457

Figure 4.

Figure 4

MicroRNA-124 (miR-124) expression and signal transducer and activator of transcription 3 (Stat3) is linked to radiotherapy resistance in vivo. (A) Western blotting for cleaved- poly (ADP-ribose) polymerase (PARP), Stat3, and p-Stat3 in SKBR3 cells treated with Dimethyl sulfoxide (DMSO) or S3I-201 and then irradiated. (B) Percentage of cell death determined by flow cytometry (C) Relative expression of Stat3 expression in recurrence-free (responder; n = 10) and relapsed (nonresponder; n = 10) human epidermal growth factor receptor 2 (HER-2)-positive breast cancer tissues determined by quantitative polymerase chain reaction. Mean expression in responders was normalized to 1. Data are presented as box-and-whisker plots. (D) Relative miR-124 expression in recurrence-free (responder; n = 10) and relapsed (nonresponder; n = 10) HER2-positive breast cancer tissues determined by qPCR. Interquartile ranges are presented as box-and-whisker plots. *P < 0.05.