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. 2016 Dec 7;6:38582. doi: 10.1038/srep38582

Figure 6. Liposomes-induced improvement of cellular uptake of QX-314 in HEK293 cells.

Figure 6

The intracellular concentration of QX-314 after 0.5 h and 4 h of incubation with 0.5 mmol/L QX-314 alone were statistically similar (in the upper left region of this figure). Anionic liposomes markedly increase the intracellular concentration of QX-314; co-incubation of neutral liposomes have limited effects on improving cellular uptake of QX-314; cationic liposomes, however, decrease cellular entry of QX-314 after 0.5 h of co-incubation. AL0.8: 0.8 mmol/L anionic liposomes; AL1.6: 1.6 mmol/L anionic liposomes; NL0.8: 0.8 mmol/L neutral liposomes; NL1.6: 1.6 mmol/L neutral liposomes; CL0.8: 0.8 mmol/L cationic liposomes; CL1.6: 1.6 mmol/L cationic liposomes. *P < 0.05; **P < 0.01; ***P < 0.001 compared to anionic liposomes at the corresponding concentration, respectively.