. 2016 Dec 7;6:38605. doi: 10.1038/srep38605

Table 3. Adjusted odds ratios (ORs) with associated 95% confidence interval (CI) for insulin resistance, metabolic syndrome and NAFLD.

Variables	Insulin resistance			Metabolic syndrome			NAFLD
Variables	OR	95%CI	P value	OR	95%CI	P value	OR	95%CI	P value
Model 1
Hyperuricemia (yes v.s. no)	1.567	1.245–1.974	<0.001^*	1.890	1.486–2.404	<0.001^*	2.370	1.864–3.012	<0.001^*
Serum uric acid^†	1.434	1.257–1.636	<0.001^*	1.581	1.374–1.818	<0.001^*	1.722	1.496–1.983	<0.001^*
Serum uric acid ^‡
(Quartile 2 vs. Quartile 1)	1.393	1.027–1.889	0.033^*	1.447	1.064–1.968	0.018^*	1.396	1.029–1.893	0.032^*
(Quartile 3 vs. Quartile 1)	2.012	1.456–2.780	<0.001^*	2.256	1.623–3.135	<0.001^*	2.552	1.844–3.533	<0.001^*
(Quartile 4 vs. Quartile 1)	2.363	1.658–3.367	<0.001^*	2.685	1.864–3.866	<0.001^*	3.524	2.445–5.079	<0.001^*
Trend test			<0.001^*			<0.001^*			<0.001^*
Model 2
Hyperuricemia (yes v.s. no)	1.565	1.242–1.973	<0.001^*	1.884	1.480–2.396	<0.001^*	2.423	1.903–3.086	<0.001^*
Serum uric acid^†	1.436	1.258–1.639	<0.001^*	1.582	1.375–1.821	<0.001^*	1.762	1.528–2.031	<0.001^*
Serum uric acid^‡
(Quartile 2 vs. Quartile 1)	1.390	1.024–1.888	0.035^*	1.441	1.059–1.962	0.020^*	1.440	1.059–1.958	0.020^*
(Quartile 3 vs. Quartile 1)	2.011	1.453–2.781	<0.001^*	2.247	1.616–3.126	<0.001^*	2.648	1.908–3.676	<0.001^*
(Quartile 4 vs. Quartile 1)	2.359	1.652–3.367	<0.001^*	2.678	1.856–3.862	<0.001^*	3.715	2.566–5.378	<0.001^*
Trend test			<0.001^*			<0.001^*			<0.001^*
Model 3
Hyperuricemia (yes v.s. no)	1.268	0.987–1.630	0.063	1.533	1.186–1.982	0.001^*	1.992	1.516–2.618	<0.001^*
Serum uric acid^†	1.231	1.067–1.420	0.004^*	1.345	1.160–1.560	<0.001^*	1.762	1.528–2.031	<0.001^*
Serum uric acid ^‡
(Quartile 2 vs. Quartile 1)	1.176	0.846–1.634	0.335	1.163	0.839–1.613	0.365	1.105	0.779–1.567	0.575
(Quartile 3 vs. Quartile 1)	1.545	1.091–2.188	0.014^*	1.652	1.165–2.342	0.005^*	1.908	1.318–2.762	0.001^*
(Quartile 4 vs. Quartile 1)	1.678	1.142–2.466	0.008^*	1.748	1.180–2.588	0.005^*	2.475	1.622–3.777	<0.001^*
Trend test			0.004^*			0.001^*			<0.001^*

^*p < 0.05.

^†OR and 95%CI was impressed by per SD increase of serum uric acid.

^‡OR and 95%CI was impressed by the first quartile of serum uric acid as the reference.

Model 1: was adjusted for sex and age. Model 2: was further adjusted for educational level, ever smoking, ever drinking and regular physical exercise. Model 3: For insulin resistance, model 3 was further adjusted for waist, systolic blood pressure, triglyceride, HDL-cholesterol; For metabolic syndrome, model 3 was further adjusted for fasting insulin; For NAFLD, model 3 was further adjusted for waist, systolic blood pressure, triglyceride, HDL-cholesterol, fasting plasma glucose and fasting insulin.