Table 2. Estimates of the effect of genetically predicted birth weight (per 100 gram)¹² with lipids¹⁷ obtained from Mendelian randomization using different methodological approaches and different exclusions for pleiotropy.

Lipid traits	Source	Method	7 SNPs		5 SNPsa		10 SNPsb
			Beta	95% CI	Beta	95% CI	Beta	95% CI
LDL cholesterol (SD)	Global Lipids Genetics Consortium	IVW	−0.0096	−0.023 to 0.004	−0.015	−0.031 to 0.002	−0.012	−0.026 to 0.0008
		WM	−0.013	−0.032 to 0.006	−0.017	−0.038 to 0.005	−0.016	−0.035 to 0.003
HDL cholesterol (SD)	Global Lipids Genetics Consortium	IVW	−0.014	−0.027 to −0.0005	−0.022	−0.038 to −0.006	−0.011	−0.024 to 0.0009
		WM	−0.007	−0.028 to 0.015	−0.036	−0.056 to −0.015	−0.005	−0.026 to 0.015
Triglycerides (SD)	Global Lipids Genetics Consortium	IVW	−0.0009	−0.013 to 0.012	0.002	−0.013 to 0.017	−0.004	−0.016 to 0.008
		WM	0.011	−0.009 to 0.032	0.019	−0.003 to 0.04	0.003	−0.017 to 0.023

^aExcluding SNPs related to height (rs724577(LCORL) and rs1042725 (HMGA2)).

^bIncluding SNPs which did not reach genome wide significance for birth weight but p value < 10⁻⁵ (rs5415 (SLC2A4); rs5758511 (CENPM); and rs7780752 (CALCR)).

HDL: High density lipoprotein; IVW: Inverse variance weighting method; LDL: Low density lipoprotein; WM: Weighted median method.