Table 1.

Dose-dependent effects of GLP-1 (7–36) on global indices of cardiac function

[GLP-1] (pmol/L)	MBP (mmHg)	HR (bpm)	+dP/dt max (mmHg/s)	−dP/dt min (mmHg/s)	CO (L/min)	SV (mL)
Coronary perfusion pressure = 100 mmHg
Baseline	80 ±4	88 ±6	1425 ±216	−1102 ±197	1.6 ±0.2	18 ±2
10	82 ±3	92 ±7	1379 ±216	−1187 ±194	1.5 ±0.2	16 ±2
100	83 ±3	99 ±9	1350 ±181	−1161 ±168	1.4 ±0.1	14 ±1*
1000	80 ±4	99 ±8	1310 ±196	−1004 ±146	1.3 ±0.1*	13 ±1*
Coronary perfusion pressure = 40 mmHg
Baseline	80 ±2	89 ±8	1228 ±174	−974 ±207	1.2 ±0.1†	13 ±1†
10	81 ±1	93 ±8	1182 ±233	−981 ±218	1.2 ±0.1	12 ±1
100	84 ±2	94 ±7	1280 ±199	−1080 ±226	1.2 ±0.1	12 ±1
1000	84 ±1	96 ±8	1232 ±228	−1035 ±207	1.1 ±0.2	11 ±2

Data are mean ±SE from n = 9 dogs

^*P < 0.05 versus baseline, same CPP.

^†P < 0.05 versus baseline, CPP = 100 mmHg

GLP-1, glucagon-like peptide-1; MBP, mean blood pressure; dp/dt, rate of pressure development; CO, cardiac output; SV, stroke volume