Table 3.
Genotype and allele frequencies of ABO C>T (rs505922), F5 C>G (rs6427196), MTHFR C>T (rs1801133), and FGG C>T (rs6536024) SNPs in morbidly obese and nonobese control individuals.
| Alleles/genotypes | Morbid obesity group (n = 320) | Control group (n = 303) | aOR | 95% CI | P |
|---|---|---|---|---|---|
| n, % | n, % | ||||
| rs505922 ABO C>T |
|||||
| T | 380 (59.4) | 373 (61.6) | |||
| C | 260 (40.6) | 233 (38.4) | 1.10 | (0.877–1.38) | 0.406 |
| TT | 107 (35.3) | 113 (37.9) | — | ||
| TC | 166 (48.2) | 147 (47.3) | 1.26 | (0.834–1.90) | 0.273 |
| CC | 47 (16.5) | 43 (14.7) | 1.06 | (0.593–1.91) | 0.836 |
| CC + TC versus TT | 1.21 | (0.819–1.79) | 0.337 | ||
| CC versus TC + TT | 0.930 | (0.546–1.58) | 0.788 | ||
| rs6427196 F5 C>G |
|||||
| G | 610 (95.3) | 571 (94.2) | |||
| C | 30 (4.7) | 35 (5.8) | 0.805 | (0.488–1.32) | 0.395 |
| GG | 291 (90.8) | 268 (88.7) | — | ||
| GC | 28 (9.0) | 35 (10.9) | 0.605 | (0.325–1.13) | 0.112 |
| CC | 1 (0.2) | 0 (0) | 1.82 × 108 | (0–inf) | 0.999 |
| CC + GC versus GG | 0.613 | (0.330–1.14) | 0.120 | ||
| CC versus GC + GG | 1.95 × 108 | (0–inf) | 0.999 | ||
| rs1801133 MTHFR C>T |
|||||
| C | 447 (70.1) | 447 (73.8) | |||
| T | 191 (29.9) | 159 (26.2) | 1.201 | (0.938–1.54) | 0.147 |
| CC | 156 (49) | 159 (54.5) | — | ||
| CT | 135 (42) | 129 (38.7) | 1.043 | (0.706–1.54) | 0.832 |
| TT | 28 (8.9) | 15 (6.9) | 1.842 | (0.837–4.05) | 0.129 |
| TT + TC versus CC | 1.127 | (0.775–1.64) | 0.532 | ||
| TT versus CT + CC | 1.808 | (0.838–3.90) | 0.131 | ||
| rs6536024 FGG C>T |
|||||
| T | 355 (55.5) | 532 (66) | |||
| C | 285 (44.5) | 274 (34) | 0.972 | (0.777–1.22) | 0.804 |
| TT | 100 (30.8) | 184 (43.6) | — | ||
| TC | 155 (49.4) | 164 (44.9) | 0.796 | (0.516–1.23) | 0.303 |
| CC | 65 (19.8) | 55 (11.6) | 1.14 | (0.660–1.97) | 0.638 |
| CC + TC versus TT | 0.881 | (0.585–1.33) | 0.545 | ||
| CC versus TC + TT | 1.31 | (0.817–2.11) | 0.260 |
aOR, adjusted odds ratio by sex and age; CI, confidence interval.