Table 2. Candidate prenyl transferase substrates from the P. falciparum 3D7 proteome, which were not identified by PrePS but possess additional, promising CaaX features.
Accession No. | Name | C-term | Mol. wt. (kDa) | Basic residue at −1 to −5 | Hydrophobic residue at +2 | Aromatic residue at +2 |
---|---|---|---|---|---|---|
Q8IIN1 | Protein tyrosine phosphatase | NCLRKCHFM | 25 | + | + | + |
Q8ILH7 | Uncharacterized protein | KKRNKCNFM | 51 | + | + | + |
Q8I3K7 | Membrane skeletal protein IMC1-related | QRNLYCSYA | 34 | + | + | + |
Q8I0W8 | Deoxyribodipyrimidine photolyase | KREKKCVAS | 129 | + | + | − |
O77306 | Ser/Thr protein kinase | NKKNSCAYT | 157 | + | + | − |
Q9NLB7 | Uncharacterized protein | NYNFLCLYI | 10 | − | + | + |
O77380 | CPSF | DLENMCSFL | 339 | − | + | + |
Underlined residues indicate putative sites for prenylation.