TABLE 1.

European LeukemiaNet Response Definitions and Monitoring Recommendations in Patients With Chronic Myeloid Leukemia

	Cytogenetic response (% Ph-positive metaphases)	Molecular response (BCR-ABL transcript level)
Definitions	Complete: 0%	Complete: transcript is nonquantifiable and nondetectable
	Partial: 1–35%
	Major: ≤35%
	Minor: 36–65%
	Minimal: 66–95%	Major: ≤0.10 ratio for BCR-ABL: standardized control gene
	None: >95%
Monitoring	Check at least every 6 mo until complete response achieved and confirmed, then at least every 12 mo	Check every 3 mo; mutational analysis in case of failure, suboptimal response, or transcript level increase

Ph indicates Philadelphia chromosome. Adapted from Baccarani 2006.⁶