Table 1.
Immunohistochemical quantification data
| PDE subtype | Sample Size, CTRL vs CRN | Mean (±SEM) CTRL vs CRN |
p-value |
|---|---|---|---|
| PDE3A | 14 vs 16 | 11404 (1209) vs 8313 (762) | 0.035 |
| PDE3B | 14 vs 16 | 4098 (829) vs 4200 (908) | 0.936 |
| PDE4A | 14 vs 16 | 16740 (1997) vs 13786 (1203) | 0.203 |
| PDE4Ba | 14 vs 16 | 4276 (640) vs 6723 (724) | 0.019 |
| PDE4C | 14 vs 16 | 16954 (1458) vs 15439 (1159) | 0.418 |
| PDE4D | 14 vs 15 | 8473 (1442) vs 6923 (936) | 0.369 |
| PDE5A | 14 vs 16 | 16614 (1514) vs 14736 (1365) | 0.363 |
Only PDE4B elicited significantly altered expression and quantification levels. P-values for PDE3A and PDE3B were calculated using Mann–Whitney rank test. All other p-values were obtained using the students t-test. A sample from the CRN group was removed for PDE4D after both blinded investigator concluded that quantification was not possible
aMarks PDE subtypes with significantly elevated expression levels