Figure 1.
State of health of β/β mice and the effect of β/β allele on the monogenic obese mutants Cpefat/fat and Lepob/ob and on weight gain induced by a high-fat diet. (A) Lifespan of β/β mice. The values depicted are the percentage of surviving mice from the original mice of each group (n = 30-40). The respiration parameters (B) and bodyweight recovery after fasting (C) in β/β mice. Each bar represents the mean ± S.E.M. (n = 6-8). (*) p < 0.05; (**) p < 0.01 between the two groups indicated. The effect of the β/β allele on weight gain induced by a high-fat diet (HF; D), and on monogenic obese mutants Cpefat/fat (E) and Lepob/ob (F). Each bar represents the mean ± S.E.M. (n = 5-8). (Std) standard diet; (*) p < 0.05; (**) p < 0.01 between the two groups of mice indicated.