Table II.
Primary hypotheses: effects of treatment condition (versus IT) on maintenance of tobacco abstinence and medication use
| Intervention versus IT | Treated-as-intended |
Intention-to-treat |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 12mPA from tobacco | ||||||||||
| Attain (%) | χ 2(1) | NNT | OR | 95% CI | Attain (%) | χ 2(1) | NNT | OR | 95% CI | |
| ENS | 15.7 versus 3.8 | 6.92** | 8.4 | 4.72 | 1.35, 16.53 | 8.4 versus 7.1 | 0.26 | — | 1.20 | 0.59, 2.44 |
| Harm reduction | 13.6 versus 3.8 | 5.26* | 10.2 | 3.99 | 1.13, 14.09 | 7.9 versus 7.1 | 0.09 | — | 1.12 | 0.55, 2.28 |
| Intervention versus IT | Days since last cigarette | |||||||||
| Mean (SD) | t(322) | Mean (SD) | t(805) | |||||||
| ENS | 115.42 (248.07) versus 22.48 (90.46) | 3.00** | 61.67 (186.04) versus 39.38 (126.82) | 1.37 | ||||||
| Harm reduction | 100.33 (233.83) versus 22.48 (90.46) | 2.53* | 55.99 (177.60) versus 39.38 (126.82) | 1.02 | ||||||
| Intervention versus IT | 7dPP tobacco abstinence | |||||||||
| Attain (%) | χ2(1) | NNT | OR | 95% CI | Attain (%) | χ2(1) | NNT | OR | 95% CI | |
| ENS | 22.3 versus 12.7 | 2.96 + | 10.4 | 1.98 | 0.90, 4.36 | 13.1 versus 14.8 | 0.27 | — | 0.87 | 0.51, 1.48 |
| Harm reduction | 20.8 versus 12.7 | 2.21 | — | 1.81 | 0.82, 4.00 | 12.3 versus 14.8 | 0.62 | — | 0.81 | 0.47, 1.38 |
| Intervention versus IT | Medication use | |||||||||
| Attain (%) | χ2(1) | NNT | OR | 95% CI | Attain (%) | χ2(1) | NNT | OR | 95% CI | |
| ENS | 77.7 versus 43.0 | 24.90*** | 2.9 | 4.61 | 2.49, 8.55 | 44.5 versus 36.1 | 3.26 + | 11.9 | 1.42 | 0.97, 2.09 |
| Harm reduction | 84.0 versus 43.0 | 37.41*** | 2.4 | 6.95 | 3.62, 13.36 | 52.2 versus 36.1 | 11.50*** | 6.2 | 1.93 | 1.32, 2.84 |
| Intervention versus IT | Days using medication | |||||||||
| Mean (SD) | t(322) | Mean (SD) | t(805) | |||||||
| ENS | 86.50 (140.85) versus 21.33 (51.04) | 3.90*** | 37.38 (97.97) versus 21.41 (58.13) | 1.94 + | ||||||
| Harm reduction | 75.67 (117.60) versus 21.33 (51.04) | 3.27*** | 36.17 (86.75) versus 21.41 (58.13) | 1.79 + | ||||||
Note. 12mPA from tobacco = 12-month prolonged abstinence from tobacco; 7dPP tobacco abstinence = 7-day point prevalence tobacco abstinence; Attain (%) = percentage who attained outcome; NNT = number needed to treat; OR = odds ratio; 95% CI = 95% confidence interval
+
P < 0.10,
*P < 0.05,
** P < 0.01,
*** P < 0.001