Table 1.

Perifusion analysis on intact islets isolated from pregnant (GD14.5) wild-type and Ctgf^LacZ/+ females

		Insulin, ng·100 IEQs−1·min−1
		Wild type			CtgfLacZ
Treatment	Fraction	Mouse 1	Mouse 2	Mouse 3	Mouse 1	Mouse 2	Mouse 3	P Value
5.6 mM Glu	1	0.21	0.24	0.26	0.14	0.18	0.56	0.69
5.6 mM Glu	2	0.20	0.10	0.22	0.15	0.21	0.32	0.46
5.6 mM Glu	3	0.12	0.26	0.20	0.20	0.13	0.34	0.70
16.7 mM Glu	4	0.16	0.11	0.15	0.14	0.18	0.55	0.31
16.7 mM Glu	5	0.11	0.30	0.12	0.31	0.33	0.42	0.06
16.7 mM Glu	6	4.54	2.22	2.12	4.32	2.05	2.66	0.97
16.7 mM Glu	7	2.22	0.93	1.10	1.95	1.44	0.86	1.00
16.7 mM Glu	8	1.41	0.89	0.97	1.33	1.36	1.84	0.14
16.7 mM Glu	9	2.60	1.46	1.02	2.51	1.77	2.04	0.47
16.7 mM Glu	10	2.70	1.40	1.51	2.84	1.97	2.10	0.43
16.7 mM Glu	11	2.62	1.30	1.65	2.59	2.23	2.11	0.34
16.7 mM Glu	12	3.15	1.19	1.65	2.16	2.34	1.90	0.83
16.7 mM Glu	13	3.41	1.89	1.70	3.00	2.06	2.51	0.77
16.7 mM Glu	14	3.36	1.39	2.21	2.63	2.90	2.48	0.58
5.6 mM Glu	15	2.85	1.42	1.48	2.93	2.09	1.96	0.50
5.6 mM Glu	16	3.38	1.29	1.73	2.39	1.86	2.66	0.81
5.6 mM Glu	17	1.27	0.56	0.52	1.37	1.10	1.51	0.11
5.6 mM Glu	18	0.51	0.26	0.32	0.58	0.59	1.22	0.12
5.6 mM Glu	19	0.27	0.22	0.18	0.53	0.42	0.96	0.07
5.6 mM Glu	20	0.14	0.12	0.21	0.27	0.34	0.68	0.10
5.6 mM Glu	21	0.13	0.21	0.16	0.30	0.25	0.42	0.05
5.6 mM Glu + 20 mM KCl	22	0.13	0.12	0.15	0.22	0.35	0.61	0.09
5.6 mM Glu + 20 mM KCl	23	0.61	0.86	0.32	1.07	0.75	1.35	0.12
5.6 mM Glu + 20 mM KCl	24	3.19	1.32	1.69	2.14	2.11	2.13	0.92
5.6 mM Glu	25	1.50	0.90	0.86	1.70	0.71	1.30	0.69
5.6 mM Glu	26	1.57	0.67	0.94	1.15	0.90	2.05	0.52
5.6 mM Glu	27	0.39	0.32	0.29	0.53	0.33	1.26	0.26
5.6 mM Glu	28	0.22	0.28	0.27	0.34	0.22	0.70	0.33
5.6 mM Glu	29	0.17	0.29	0.18	0.18	0.22	0.60	0.43
5.6 mM Glu	30	0.15	0.13	0.14	0.18	0.17	0.37	0.22
5.6 mM Glu	31	0.17	0.20	0.15	0.19	0.10	0.40	0.55

GD14.5, gestational day 14.5; CTGF, connective tissue growth factor; IEQ, islet equivalent; Glu, glucose.

Insulin measurements (ng·100 IEQs⁻¹·min⁻¹) of each sample for each treatment and effluent fraction. P values calculated using Student's t-test.