Table 1.

Knowledge gaps related to alcohol, circadian clocks, and alcoholic liver disease

Alcohol, Circadian Clocks, and Alcoholic Liver Disease
Identify clock-regulated targets/programs mediating alcohol-induced alterations in metabolism
Reveal mechanism(s) of alcohol-mediated clock disruption
Importance of liver cell-specific clocks in alcohol-induced liver injury–hepatocyte vs. stellate cell vs. Kupffer cell
Under investigation and development of chrono-pharmacological agents and/or strategies to treat alcoholic liver injury and other alcohol-related pathologies