Table 2.
Unadjusted competing risk regression for ESRD showing concepts with q values <0.05 (top 10 positive and negative predictors shown; full results are in Supplemental Table 1)
| UMLS CUI | Most Common Phrase (Three Most Correlated Phrases [Φ-Coefficient]) | HR [95% CI] | q Value | Prevalence (%) |
|---|---|---|---|---|
| Top 10 positive predictors (HR>1) by q value (lowest to highest) | ||||
| C0022661 | Chronic renal insufficiency (CKD [0.77], chronic disease [0.71], renal insufficiency [0.66]) | 5.07 [3.52 to 7.31] | <0.001 | 15.9 |
| C0022658 | Nephropathy (renal impairment [0.89], renal insufficiency [0.81], CKD [0.7]) | 3.45 [2.44 to 4.89] | <0.001 | 17.2 |
| C0917873 | Dialysisa (hemodialysis [0.38], ESRD [0.34], uremia [0.3]) | 4.64 [3.01 to 7.17] | <0.001 | 5.6 |
| C0011946 | Dialysisa (hemodialysis [0.37], ESRD [0.34], uremia [0.3]) | 4.64 [3.01 to 7.16] | <0.001 | 5.6 |
| C0403447 | CKD (chronic disease [0.92], renal impairment [0.78], chronic renal insufficiency [0.77]) | 3.36 [2.38 to 4.73] | <0.001 | 21.9 |
| C0035078 | Renal insufficiency (renal impairment [0.91], nephropathy [0.81], chronic renal insufficiency [0.66]) | 3.55 [2.47 to 5.11] | <0.001 | 25.4 |
| C0546817 | Volume overload (diuresis [0.61], diuresed [0.6], BNP [0.52]) | 3.85 [2.54 to 5.84] | <0.001 | 7.2 |
| C0020223 | Hydralazine (hydralazine HCl [0.65], labetalol [0.33], CK-MB [0.29]) | 4.01 [2.54 to 6.33] | <0.001 | 4.4 |
| C0699992 | Lasix (furosemide [0.74], sulfonamide [0.61], furosemide 40 mg [0.51]) | 2.82 [2.00 to 3.97] | <0.001 | 19 |
| C0016860 | Furosemide (sulfonamide [0.8], lasix [0.74], furosemide 40 mg [0.66]) | 2.84 [1.99 to 4.07] | <0.001 | 13.6 |
| Top 10 negative predictors (HR<1) by q value (lowest to highest) | ||||
| C0227391 | Sigmoid (descending colon [0.43], transverse colon [0.36], large bowel [0.33]) | <0.01 [<0.01 to <0.01] | <0.001 | 6.6 |
| C1299496 | Radiology report (anion gap [0.14], 3.9 [0.14], pigment [0.13]) | <0.01 [<0.01 to <0.01] | <0.001 | 4.1 |
| C0231953 | Lung volumes (FRC [0.46], diffusing capacity [0.45], atelectasis [0.36]) | <0.01 [<0.01 to <0.01] | <0.001 | 4.6 |
| C0014672 | Equipment (procedure/site [0.42], knowledge deficit [0.4], nursing care [0.36]) | <0.01 [<0.01 to <0.01] | <0.001 | 4.7 |
| C0221103 | Suppression (acid [0.24], suppressed [0.17], bone marrow [0.15]) | <0.01 [<0.01 to <0.01] | <0.001 | 4.1 |
| C0439181 | Suppression (acid [0.24], suppressed [0.17], bone marrow [0.15]) | <0.01 [<0.01 to <0.01] | <0.001 | 4.1 |
| C0086930 | Risk assessment (homicidal ideation [0.73], abnormal movements [0.65], suicidal ideation [0.65]) | <0.01 [<0.01 to <0.01] | <0.001 | 4.5 |
| C0184924 | Punch biopsy (punch biopsy [0.99], punch [0.58], suture removal [0.57]) | <0.01 [<0.01 to <0.01] | <0.001 | 3.4 |
| C0700201 | Sleep disturbance (fear of falling [0.55], skin problems [0.51], sleep disorder [0.43]) | <0.01 [<0.01 to <0.01] | <0.001 | 4.4 |
| C0014180 | Endometrium (myometrium [0.63], right ovary [0.5], right ovary [0.5]) | <0.01 [<0.01 to <0.01] | <0.001 | 3.3 |
UMLS CUI, Unified Medical Language System concept unique identifier; HR, hazard ratio; 95% CI, 95% confidence interval; BNP, B-type Natriuretic Peptide; CK-MB, creatine kinase-myocardial band; FRC, functional residual capacity.
a
Note that the phrase dialysis maps to two concepts, because we used settings in MetaMap that allowed a phrase to match multiple concepts (instead of choosing only one).