Table 1.

Characteristics of 30 boys and men with Dent disease at renal biopsy

Patient Study No.	Demographics					Clinical Features
	Age at Kidney Biopsy, yr	Country of Origin	Race	Relationship to Any Other Patient	Genetically Confirmed Type of Dent Disease	eGFR, ml/min per 1.73 m2	Increased Urinary LMWP	Hypercalciuria	History of Kidney Stones	Rickets
1	1	Spain	White		1	67	Yes	Yes	No	Yes
2	7	United States	White		1	117.9	ND	ND	No	ND
3	40	United States	White		1	48.0	Yes	No	No	ND
4	11	United States	White		1	99.04	Yes	Yes	No	ND
5	3	Canada	White		1	31.4	ND	ND	No	No
6	15	United States	White		1	69.19	ND	ND	Yes	No
7	19	Uruguay	White		1	39.0	Yes	No	No	No
8	5	England	White		1	110.57	Yes	Yes	No	No
9	8	United States	White		1	63.7	Yes	ND	No	No
10	38	Ethiopia	Other (including two or more races)		Not type 1 or 2	6.0	Yes	No	Yes	No
11	1.5	United States	Asian		1	79.12	Yes	Yes	No	ND
12	4	United States	White		1	90.47	Yes	Yes	No	ND
13	7	United States	Black	Brother to 14	2	38.73	Yes	Yes	No	ND
14	7	United States	Black	Brother to 13	2	81.7	Yes	Yes	No	ND
15	11	United States	White		1	57.3	Yes	Yes	Yes	No
16	27	United States	White	Brother to 19	1	20	Yes	Yes	No	No
17	7	United States	White		1	142.2	Yes	Yes	No	ND
18	5	Algeria	White		1	64.1	Yes	Yes	No	ND
19	21	United States	White	Brother to 16	1	55.0	ND	Yes	No	No
20	6	United States	White		1	171.28	Yes	Yes	ND	No
21	19	England	White		1	18	ND	Yes	ND	Yes
22	12	United States	White		1	76	ND	Yes	No	No
23	7	United States	White		1	79.5	Yes	Yes	No	No
24	5	United States	White		1	70.03	Yes	Yes	No	No
25	30	United States	White		1	28.0	Yes	ND	No	No
26	6	Italy	White		1	88	Yes	No	No	Yes
27	9	Italy	White		1	114	Yes	Yes	Yes	No
28	11	Italy	White		1	97	Yes	Yes	No	No
29	3	Italy	White		1	ND	Yes	No	No	No
30	48	Italy	White		Not type 1 or 2	63	Yes	Yes	Yes	No
Overall	7.5 (5, 19)		86% White		86% Dent disease 1	69 (44, 94)	100%	80%	18%	14%

Data for overall are presented as medians (25th, 75th percentiles) or percentages. Note that, for patients younger than 18 years of age, eGFR was calculated using the Schwartz formula (13). For patients older than 18 years of age, eGFR was calculated using the Modification of Diet in Renal Disease equation (14). LMWP, low molecular weight proteinuria; ND, not determined or not available.