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. 2016 Oct 17;214(12):1856–1864. doi: 10.1093/infdis/jiw488

Figure 5.

Figure 5.

Bumped kinase inhibitor (BKI) treatments reduce fecal oocyst shedding in calves having an established Cryptosporidium parvum infection. A, Daily oocyst shedding was significantly reduced in BKI-1294– and BKI-1517–treated calves on days 3–10 after infection (P < .05), compared with values for control calves. Daily oocyst shedding was significantly reduced in BKI-1553–treated calves on days 3 and 8–10 after infection (P < .05). B, The total number of oocysts shed over the duration of the trial was significantly reduced in BKI-1294–treated calves and BKI-1517–treated calves but not BKI-1553–treated calves, compared with control calves (P < .05), with BKI-1294 having a greater effect than BKI-1517 (P < .005). Data are for 18 control calves and 6 calves per BKI. Oocyst counts (daily and total) were examined for significant differences by the 1-tailed Student t test. Abbreviation: SD, standard deviation.