Figure 7.

Phoenix WinNonlin was used to predict the plasma concentrations of bumped kinase inhibitors (BKIs) after delivery of multiple doses of BKI-1517 (10 mg/kg orally twice daily for 5 days; 10 total doses; A), BKI-1553 (5 mg/kg orally twice daily for 5 days; 10 total doses; B), and BKI-1294 (5 mg/kg orally twice daily for 5 days [10 total doses; C] or 10 mg/kg orally every other day for 8 days [4 total doses; D]). The dot and whisker plots represent average measured plasma BKI concentrations ± SDs. The only concentrations not predicted well were the BKI-1517 concentrations after the first dose (A). However, the concentrations after the fifth dose were predicted.