Figure 2.

EEG and MRI Analysis of Individuals from Family 1

(A) Wakeful EEG of individual II-7 from family 1. Interictal activity (green background) is characterized by near-continuous independent or synchronous bilateral or generalized bifrontally dominant spike-wave discharges. Ictus (seizure; yellow background) is associated with continuous generalized bifrontally dominant rhythmic activity.

(B and C) MRI demonstrating dysgenesis of the corpus callosum (arrows) and ventriculomegaly in affected individuals II-6 (B) and II-7 (C), as well as Dandy-Walker malformation, a posterior fossa cyst, hypoplastic vermis, and diffuse hydrocephalus in individual II-6.