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. 2016 Nov 17;99(6):1245–1260. doi: 10.1016/j.ajhg.2016.10.003

Figure 1.

Figure 1

Overview of Our Method for Detecting the Target Gene and Most Relevant Tissue

We compute the CLPP for all genes and all tissues.

(A) A simple case where we have only one tissue and want to find the target gene. We consider all genes for this GWAS risk locus and observe that gene 4 has the highest CLPP. Thus, the target gene is gene 4.

(B) We have three tissues and utilize the quantity of CLPP. Thus, the target gene is gene 4 again. Moreover, in this example, liver and blood are considered the relevant tissues for this GWAS risk locus, whereas the pancreas is not relevant.