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. 2016 Aug 19;311(4):L743–L753. doi: 10.1152/ajplung.00238.2016

Fig. 4.

Fig. 4.

A: BH4 levels in small pulmonary arteries from control (normoxic) and chronically hypoxic piglets. BH4 levels were greater in small pulmonary arteries from normoxic control piglets (n = 6) than in all groups of hypoxic piglets. BH4 levels were greater in small pulmonary arteries from chronically hypoxic piglets receiving either low-dose (n = 4) or high-dose (n = 6) oral BH4 treatment than in small pulmonary arteries from untreated chronically hypoxic piglets (n = 6). BH4 levels were greater for pulmonary arteries from high-dose compared with low-dose oral BH4-treated chronically hypoxic piglets. B: BH2 levels in small pulmonary arteries from control (normoxic) and chronically hypoxic piglets. BH2 levels were less in small pulmonary arteries from normoxic control piglets (n = 6) than in all groups of hypoxic piglets. BH2 levels were less in small pulmonary arteries from chronically hypoxic piglets receiving either low-dose (n = 4) or high-dose (n = 6) oral BH4 treatment than in small pulmonary arteries from untreated chronically hypoxic piglets (n = 6). BH2 levels were less for pulmonary arteries from high-dose compared with low-dose oral BH4-treated chronically hypoxic piglets. C: BH4-to-BH2 ratios (BH4/BH2) in small pulmonary arteries from control (normoxia) and chronically hypoxic piglets. BH4/BH2 were greater in small pulmonary arteries from normoxic control piglets (n = 6) than in all groups of hypoxic piglets. BH4/BH2 were greater in small pulmonary arteries from the high-dose oral BH4-treated group of chronic hypoxic piglets (n = 6) than in the untreated group of chronic hypoxic piglets (n = 6). D: BH4+BH2 levels in small pulmonary arteries from control (normoxia) and chronically hypoxic piglets. BH4+BH2 ratios were greater in small pulmonary arteries from normoxic control piglets (n = 6) than in the untreated (n = 6) or low-dose oral BH4-treated (n = 4) groups of chronic hypoxic piglets. Values are means ± SE. Different from *control (normoxic), +untreated chronic hypoxic, and !low-dose BH4-treated chronic hypoxic: P < 0.05; ANOVA with post hoc comparison test.