Fig. 6.

A: representative Western blot for eNOS dimer-to-monomer ratios with corresponding densitometry shows that small pulmonary arteries from both low- and high-dose oral BH₄ (sapropterin dihydrochloride)-treated groups of chronic hypoxic piglets had greater eNOS dimer-to-monomer ratios than untreated hypoxic animals. In addition, eNOS dimer-to-monomer ratios were greater for pulmonary arteries from high-dose compared with low-dose oral BH₄-treated chronically hypoxic piglets. B: representative Western blot for eNOS expression with corresponding densitometry shows that eNOS expression was similar in small pulmonary arteries from all groups of piglets. Values are means ± SE. Different from *control (normoxic), ⁺untreated chronic hypoxic, and !high-dose BH₄-treated chronic hypoxic: P < 0.05; ANOVA with post hoc comparison test.