Fig. 7.

Representative Western blot for NOX1 with corresponding densitometry shows that small pulmonary arteries from both low- and high-dose oral BH₄ (sapropterin dihydrochloride)-treated groups of chronic hypoxic piglets had lower NOX1 expression than untreated hypoxic animals. In addition, NOX1 expression was less for pulmonary arteries from high-dose compared with low-dose oral BH₄-treated chronically hypoxic piglets. Different from *control (normoxic), ⁺untreated chronic hypoxic, and !high-dose BH₄-treated chronic hypoxic: P < 0.05; ANOVA with post hoc comparison test.