Table 1.

Data for normoxic (control), chronic hypoxic, and oral BH₄-treated chronic hypoxic piglets

Treatment Group	N	Weight, kg	LVEDP, cmH2O	Cardiac Output, ml·min−1·kg−1	Aortic Pressure, cmH2O	pH	Pao2, Torr	Paco2, Torr
Controls(normoxic)	10	3.65 ± 0.23	4.3 ± 0.4	383 ± 26	82 ± 3	7.33 ± 0.02	91 ± 3	35 ± 1
Chronic hypoxic	8	2.5 ± 0.16*	5.3 ± 0.3	349 ± 18	77 ± 3	7.39 ± 0.02	93 ± 8	34 ± 1
Low-dose BH4-treated chronic hypoxic	4	2.61 ± 0.16*	5.3 ± 1	305 ± 12	78 ± 6	7.36 ± 0.01	89 ± 3	34 ± 2
High-dose BH4-treated chronic hypoxic	12	2.65 ± 0.09*	4.8 ± 0.3	428 ± 15*+!	76 ± 2	7.35 ± 0.01	95 ± 4	34 ± 1

Values are means ± SE; N, no. of animals.

LVEDP, left ventricular end-diastolic pressure; Pao₂, arterial Po₂; Paco₂, arterial Pco₂. Different from

^*normoxic controls,

⁺chronic hypoxia, and

^!low-dose oral BH₄ (sapropterin dihydrochloride)-treated chronic hypoxic (P < 0.05; ANOVA with post hoc comparison test).