Table 1.

In vivo P. berghei intravenous (IV) sporozoite challenge causal prophylactic and erythrocytic models

Model	Causal prophylactic model	Erythrocytic treatment model
Drug administration (day)a	−1, 0, and/or +1	+4
Endpointb	Hepatic and erythrocytic parasites (asexual parasitemia)	Erythrocytic parasites: parasitemia (asexual), gametocytemia (sexual)
Technique	IVIS (liver), flow cytometry (parasitemia)	Flow cytometry (parasitemia) microscopy (gametocytemia)

^aDay of drug administration relative to IV sporozoite inoculation (day 0). IVIS In vivo imaging system

^bAnimals are monitored for 30 days or recrudescence and subsequent euthanasia due to comorbidities