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. 2016 Dec 7;35:191. doi: 10.1186/s13046-016-0469-x

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Schematic diagram of the mechanism by which srGAP1 mediating the tumor-suppressive activity of Slit2 in CRC. Slit2 inhibits CRC cell migration through the srGAP1-Cdc42 axis, and USP33 is required for the inhibitory function of Slit2-Robo1 by deubiquitinating and stabilizing Robo1 as well as taking part in the redistribution of Robo1 to the plasma membrane stimulated by Slit2

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