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A schematic diagram comparing the changes observed for selected oxylipins in response to short-lived ischemia and their possible impact on CRH between sEH−/− and sEH+/+ mice. sEH deletion enhanced CRH possibly through increased 14,15-EET/DHET ratio, increased 13-HODE, and increased EpOME/DiHOME ratio. Role of NO, PPARγ, and midchain HETEs was comparable in both sEH−/− and sEH+/+ mice.
