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. 2016 Aug 3;311(4):R676–R688. doi: 10.1152/ajpregu.00237.2016

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Copyright © 2016 the American Physiological Society

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Fig. 2. — Comparison of coronary reactive hyperemia (CRH) between wild type (sEH^+/+) and sEH^−/− (sEH-null) mice. A: tracing depicting coronary flow changes at baseline (before CRH) and after CRH was induced by 15-s no-flow ischemia in both sEH^+/+ (dash line) and sEH^−/− (continuous line) mice. Repayment volume (B; P < 0.001) and repayment/debt ratio (C; P = 0.0004) were enhanced in sEH^−/− vs. sEH^+/+ mice. Repayment duration (D) was increased in sEH^−/− vs. sEH^+/+, but did not reach statistical significance (P = 0.31). Peak hyperemic flow, baseline coronary flow, left-ventricular developed pressure (LVDP) and heart rate (HR) were not significantly different between the two groups (data not shown). *P ≤ 0.05 sEH^+/+. n = 12 per group.