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. 2016 Aug 3;311(4):R676–R688. doi: 10.1152/ajpregu.00237.2016

Fig. 5.

Fig. 5.

LC-MS/MS analysis of 9,–10-epoxyoctadecaenoic acids (EpOMEs) and dihydroxyoctadecaenoic acids (DiHOMEs) in sEH+/+ and sEH−/− mouse heart perfusate samples at baseline (preischemia) and directly after 15-s ischemia (postischemia). A: 9,10-EpOME was increased at baseline (P = 0.03) and postischemia, but was not statistically significant (P = 0.21), whereas 12,13-EpOME was increased both at baseline and postischemia (P = 0.03) in sEH−/− vs. sEH+/+ mice. B: 9,10- and 12,13-DiHOMEs were decreased at baseline (P = 0.001), and post-ischemia (P < 0.001) in sEH−/− vs. sEH+/+ mice. A decreasing trend in EpOMEs postischemia compared with baseline was observed in sEH−/− mice, but was not statistically significant. C: 9,10- and 12,13-EpOME/DiHOME ratios were increased at baseline (P = 0.002) and postischemia (P = 0.0008). *P ≤ 0.05 vs. baseline sEH+/+. #P ≤ 0.05 vs. postischemia sEH+/+. n = 7 sEH+/+, n = 10 sEH−/−.