Table 3.
Biochemical plasma analyses
|
Atg7+/+Alb-Cre+ |
Atg7F/FAlb-Cre+ |
||||||
|---|---|---|---|---|---|---|---|
| n | Means ± SE | Range, min-max | n | Means ± SE | Range, min-max | P Value | |
| AST, U/l | 15 | 175.1 ± 22.4 | 60.20–360.70 | 10 | 1855.1 ± 279.9 | 770.00–3636.00 | † |
| ALT, U/l | 15 | 20.1 ± 2.6 | 8.00–42.30 | 10 | 737.7 ± 146.2 | 168.30–1682.00 | † |
| ALP, U/l | 15 | 127.6 ± 8.2 | 78.30–203.40 | 10 | 335.7 ± 12.5 | 283.80–383.20 | † |
| GGT, U/l | 15 | 5.6 ± 0.2 | 5.00–6.60 | 10 | 14.4 ± 0.7 | 12.00–18.70 | † |
| Total cholesterol, mg/dl | 15 | 73.5 ± 4.1 | 50.00–97.40 | 10 | 140.8 ± 8.2 | 96.50–171.90 | † |
| HDL cholesterol, mg/dl | 15 | 63.5 ± 5.2 | 6.60–87.80 | 9 | 129.3 ± 7.6 | 88.50–150.00 | † |
| LDL cholesterol, mg/dl | 15 | 6.6 ± 0.8 | 2.90–16.00 | 10 | 12.8 ± 2.1 | 1.00–19.80 | * |
| LDL/HDL ratio | 15 | 0.2 ± 0.2 | 0.03–2.42 | 9 | 0.1 ± 0.0 | 0.01–0.15 | 0.46 |
| Triglycerides, mg/dl | 15 | 67.9 ± 7.7 | 40.20–121.60 | 10 | 15.1 ± 3.8 | 3.00–39.10 | † |
| Glucose, mg/dl | 15 | 106.9 ± 5.7 | 80.70–144.70 | 10 | 87.4 ± 6.4 | 54.80–115.10 | * |
| Insulin, ng/ml | 16 | 0.3 ± 0.0 | 0.20–0.70 | 11 | 0.3 ± 0.0 | 0.20–0.40 | 0.54 |
Applicable values are means ± SE. Main characteristics of autophagy-competent (Atg7+/+Alb-Cre+) and autophagy-deficient (Atg7F/FAlb-Cre+) mice are shown. Sample size (n) varies depending on the plasma volume available for each mouse.
*
P < 0.05;
†
P < 0.001.
AST, aspartate transaminase; ALT, alanine transaminase; GGT, γ-glutamyl transferase; ALP, alkaline phosphatase.