Fig. 13.

Loss of GR1+ cells contributes to TH1 and TH17 responses during γ-herpesvirus-induced fibrosis following BMT. A and B: 7 dpi, cells were harvested from collagenase-digested lungs of either control WT BMT, control CCR2^−/− BMT, or αGR1-treated WT or CCR2^−/− BMT mice (n = 4–5 mice per group, repeated once with similar results) and stained for CD4+,IFN-γ+ (TH1) or CD4+,IL-17+ (TH17) cells. C: lungs were harvested 7 dpi and infectious virus was quantified by plaque assay on NIH 3T12 monolayers. Mean values per lung are shown ±SE. Statistical significance was calculated by ANOVA, *P < 0.05, **P < 0.01.