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Inhibition of EP3 increases urine excretion in rats ingesting high salt. The increase in urine production induced by 1% NaCl intake was augmented in rats treated with L-798106, a selective EP3 receptor antagonist, suggesting that inhibition of EP3 facilitates the diuretic effects of PGE2. Data are shown as means ± SE; n = 6/group. *P < 0.05.
