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Effects of EP3 activation and inhibition on water intake and urine output under normal- and high-salt conditions. Water intake and urine output were determined after pretreatment with sulprostone (A and B) or L-798106 (C and D) for 3 days in rats ingesting tap water or 1% NaCl for 3 days concomitant with the continuation of drug treatment. The data are presented as means ± SE; n = 6.
