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L-798106 decreases AQP2 protein expression in the inner medulla. Expression of AQP2 protein was analyzed by Western blotting of inner medullary homogenates after inhibition of EP3 receptors. The data are consistent with those showing an increase in urine output in response to elevated NaCl intake in rats treated with L-798106. The lanes represent data from individual rats; 3 similar experiments were performed. The data in the histogram are presented as means ± SE; n = 6.
