Fig. 3.
Characterization of physical parameters of Ang II- or saline-infused mice. A: compared with saline-infused mice, systolic blood pressure (SBP) was increased in Ang II-infused mice, with no significant differences between HBlox/lox and HBendo−/− mice. B: telemetry studies were performed on Ang II-infused mice (n = 4 in each group). There were no significance differences between Ang II-infused HBlox/lox and HBendo−/− mice. In both groups, increased SBP levels were detected 2 days after Ang II infusion peaked around 4 days and remained elevated until the end of the experiment. C: heart rate profiles recorded by telemetry. There is an 8–10% increase in heart rate after Ang II infusion, with comparable levels in both groups (P > 0.05). D: mice body weight (BW) was slightly decreased after 4-wk Ang II infusion, whereas no significant differences were detected compared with saline-infused mice. E: at the end of the study, kidney and heart were weighed. No significant differences were seen in kidney weight (KW)/BW ratios in either Ang II- or saline-infused mice. F: compared with Ang II-infused HBlox/lox mice, HBendo−/− mice with endothelial HB-EGF deletion significantly reduced cardiac hypertrophy, indicated by lower heart weight (HW)/BW ratios. All the results shown are means ± SE of 6–7 mice in each group. *P < 0.05.