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. 2016 Dec 7;4:21. doi: 10.1186/s40170-016-0162-8

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Proposed model of impact of obesity and weight control interventions on the outcome of dacarbazine therapy in melanoma. Obesity-associated factors impair the response of melanoma to DTIC by enhancing the levels of tumor-promoting molecules (solid red arrow marks). On the other hand, controlling obesity through weight interventions causes normalization in obesity-associated factors. This in turn improves the efficacy of DTIC through reducing in the levels of melanoma cell growth promoting molecules (dotted blue arrow marks)