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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Mol Carcinog. 2016 Jan 19;55(12):2168–2182. doi: 10.1002/mc.22459

Figure 2.

Figure 2

cBioPortal analysis of genes deregulated by (S)-NNN in rat esophageal mucosa and oral mucosa showed similar alterations in human esophageal carcinoma and head and neck squamous cell carcinoma TCGA data sets. (A) OncoPrint of genes upregulated by (S)-NNN (p < 0.05) in rat esophagus showing copy number alteration (CNA) and/or deep deletion in human esophagus carcinoma (ESCA). (B) OncoPrint of genes downregulated by (S)-NNN (p < 0.05) in rat esophagus and showed CNA and/or deep deletion in human ESCA. (C) OncoPrint of genes upregulated by (S)-NNN (p < 0.05) in rat oral cavity and showed CNA, deep deletion, missense mutation, mRNA upregulation/downregulation, and/or truncating mutation in human HNSCC. (D) OncoPrint of genes downregulated by (S)-NNN (p < 0.05) in rat oral cavity and showed CNA, deep deletion, mRNA downregulation/upregulation, missense mutation, and/or truncating mutation in human HNSCC.