Table 2.
Genes deregulated by (S)-NNN in rat oral cavity tissues are also altered in human head and neck squamous cell carcinoma (HNSCC) using TCGAa.
| Rat Oral Cavity RNA-seq | Human TCGA HNSCC RNA-Seq | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| Rat gene ID | Human Symbol | Fold Change | p-value | Fold Change | p-value | FDR |
| Gip | GIP | 19.1 | 0.00401 | 9.0 | 9.63E-14 | 1.84E-13 |
| Ano3 | ANO3 | 11.8 | 0.00713 | 2.1 | 1.08E-05 | 1.16E-05 |
| Aire | AIRE | 11.6 | 0.0212 | 2.4 | 2.22E-06 | 2.52E-06 |
| Apba2 | APBA2 | 5.2 | 0.00159 | 6.3 | 5.52E-24 | 1.67E-23 |
| Gria3 | GRIA3 | 4.2 | 1.02E-07 | 4.8 | 1.88E-18 | 4.59E-18 |
| Pou2f2 | POU2F2 | 4.1 | 0.0477 | 2.3 | 2.71E-07 | 3.27E-07 |
| Cd80 | CD80 | 3.9 | 0.000908 | 4.8 | 1.84E-18 | 4.49E-18 |
| Spta1 | SPTA1 | 3.5 | 0.00929 | 3.3 | 1.62E-10 | 2.49E-10 |
| Dgkg | DGKG | 3.1 | 0.0008 | 2.5 | 1.51E-08 | 2.01E-08 |
| Gdf6 | GDF6 | 2.9 | 0.0194 | 5.8 | 7.89E-21 | 2.12E-20 |
| Kcnb2 | KCNB2 | 2.9 | 0.0373 | 2.0 | 1.68E-05 | 1.79E-05 |
| Tfpi2 | TFPI2 | 2.8 | 0.0482 | 6.5 | 1.77E-24 | 5.47E-24 |
| Rsad2 | RSAD2 | 2.4 | 0.0172 | 5.6 | 9.79E-22 | 2.74E-21 |
| Itga2b | ITGA2B | 2.2 | 0.0452 | 3.0 | 2.92E-10 | 4.41E-10 |
| Lsamp | LSAMP | 2.2 | 0.0272 | 3.1 | 1.20E-11 | 2.00E-11 |
| RGD1559864 | KIAA1045 | 2.2 | 0.0382 | 4.8 | 6.70E-19 | 1.67E-18 |
| Tbx18 | TBX18 | 2.2 | 0.00482 | 3.2 | 4.77E-12 | 8.20E-12 |
| Slc16a7 | SLC16A7 | −2.1 | 0.00191 | −4.3 | 6.99E-36 | 2.93E-35 |
| Gjb1 | GJB1 | −2.6 | 0.000908 | −15.3 | 1.04E-157 | 1.77E-156 |
| Rhcg | RHCG | −2.6 | 0.0368 | −7.6 | 1.93E-78 | 1.59E-77 |
| Dcdc2 | DCDC2 | −3.3 | 0.00328 | −2.3 | 1.38E-10 | 2.14E-10 |
| Cyp2b1 | CYP2B6 | −3.6 | 0.0159 | −7.7 | 2.21E-66 | 1.56E-65 |
| Gnat3 | GNAT3 | −4.6 | 0.039 | −3.0 | 1.05E-09 | 1.53E-09 |
| Sgk2 | SGK2 | −6.3 | 0.0221 | −6.7 | 4.75E-65 | 3.30E-64 |
| Chia | CHIA | −6.7 | 0.00186 | −2.3 | 5.49E-06 | 6.05E-06 |
| Myh8 | MYH8 | −7.2 | 0.0183 | −3.0 | 2.92E-19 | 7.37E-19 |
| Hnf1b | HNF1B | −155.9 | 0.00772 | −8.9 | 1.32E-74 | 1.04E-73 |
a
Fold changes represent changes in (or ratio of) mRNA expression levels in comparison to untreated animals or normal adjacent tissues. Negative fold changes represent downregulation in mRNA expression at the indicated ratios. FDR, false discovery rate.