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Experimental design. Twelve female C57BL/6 mice were assigned to load bearing (LB) or hindlimb suspension (HS) for 5 days (n = 6/group). All mice received irradiation (IRR) (0.5 Gy X-ray) to the right hindlimb on day 3 of the study. The left hindlimb served as the nonirradiated intra-animal control. All mice were killed on day 5 of the study.
