Table 2.
FOXP3 epigenetic studies investigated for association with asthma and allergy
| Author(s) | Year | n (cases/controls) | Epigenetic marker analyzed | Cell population analysed |
|---|---|---|---|---|
| Nadeau et al. | 2010 | 32 (16/16) | CpG methylation | Treg cells (CD4+CD25hiCD127lo) and effector T (Teff) cells (CD4+CD25lo/neg) |
| Brunst et al. | 2013 | 71 (15/56) | CpG methylation | Buccal cells in saliva |
| Runyon et al. | 2012 | 42 (21/21) | CpG methylation | Treg cells (CD4+ CD25hiCD127lo/neg) and Teff CD4+CD25neg |
| Kohli et al. | 2012 | 102 (37/65) | CpG methylation | Treg cells (CD4+ CD25hiCD127lo) and Teff CD4+CD25neg |
| Lluis et al. | 2014 | 43 | CpG methylation | Whole blood |
| Michel et al. | 2013 | 95 (45/50) | CpG methylation | Cord blood and whole blood |