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Inhibition of PI3-kinase inhibits DRA by the same pathway as disruption of raft integrity. HEK/EGFP-DRA cells were treated with 1 mM MCD at 37°C for 60 min or with MCD and LY294002 (1 mM MCD, 37°C, 60 min; 50 μM LY294002, 37°C, 30 min) prior to the functional experiment. A: simultaneous incubation with MCD and LY294002 did not further decrease DRA activity compared with the incubation with MCD alone. B: summary of the maximal (max.) pHi change.
