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Working model for exocytic trafficking of DRA and the role of lipid rafts, PI3-kinase, and PDZ adaptor proteins. PI3-kinase is required for insertion of DRA into the plasma membrane. DRA is present in lipid rafts even before the action of PI3-kinase takes place. DRA interacts with one or several PDZ adapter proteins in lipid rafts, and this interaction is required for exocytosis of DRA. TGN, trans-Golgi network.
