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. 2016 Jun 24;311(2):L389–L399. doi: 10.1152/ajplung.00171.2016

Fig. 3.

Fig. 3.

Activation of endogenous plasminogen results in a significant increase in the suppressed fibrinolytic activity in baseline pleural fluids from rabbits with P. multocida and S. pneumoniae EMP and humans from the MIST2 clinical trials. Aliquots of pleural fluid withdrawn prior to IPFT were analyzed by FITC-fibrin film fibrinolytic activity assay (26) with (○) or without (●) supplementation with 5 nM of 2-chain urokinase (tcuPA) (13). A significant increase in the baseline fibrinolytic activity occurred after supplementation with exogenous fibrinolysin (○) as observed in pleural fluid samples of (from left to right) rabbits with P. multocida and S. pneumoniae-induced EMP and humans from the MIST2 trials.