Fig. 5.

E₂ prevents worsening of cardiopulmonary hemodynamics after acute exercise. Effects are shown of OVX and E₂ repletion on RV systolic pressure (RVSP; A), stroke volume index (SVI; B), and total pulmonary resistance index (TPRi; C) after acute exercise. Values are depicted as fold change vs. values in unexercised control rats. Values >1 represent increase compared with unexercised controls; values <1 represent decrease. Note that postexercise hemodynamics remained unchanged or improved in intact female or E₂-replete OVX female SuHx rats, whereas postexercise RVSP and TPRi increased in OVX female SuHx rats. SuHx exposure, OVX, and E₂ repletion were as outlined in Fig. 1. Values are means ± SE; N = 5–8/group. P < 0.05 vs. #female SuHx and °female OVX SuHx (one-way ANOVA with post hoc Tukey's or Dunnett's test). ex, Exercised.